The result of this study on chemical selection for leaf spot disease control of Polygonatum sibiricum Redoute was as follows. Pyraclostrobin, Polyoxin B, Pyribencarb, and Iminoctadine tris(albesilate) showed excellent control value with over 80% and no damages. Above chemicals were considered excellent as chemicals for leaf spot disease in Polygonatum sibiricum Redoute.